206-486-1690 | 844-778-7074

AMT Patient Articles

A collection of articles related to well-being and cancer and chronic disease therapies.

Mistletoe in Medicine

From Mark Clinic Healing House
Original Post here: https://martin-clinic.com/?p=153

 

Dr. Anderson highlights this article by Mark Hancock, MD MPH on the different methods of using mistletoe in the treatment of cancer.

Mistletoe in medicine

Mistletoe has been used for the treatment of cancer since 1917. This article will describe several different methods of using mistletoe. We will cover the most aggressive therapy down to supportive therapy and then mention special uses of mistletoe including bladder instillation for bladder cancer as well as other therapeutic approaches of interest. Scientific literature exists on most of these approaches and I will attempt to sketch the supporting studies. This does not serve as individual direction for patients, only as information for a better understanding of different approaches with mistletoe.

Heat Seeking Mistletoe Therapy

This approach is used in several European centers such as the Oeschelbronn clinic as well as the Martin Clinic. Very high dose, high lectin content mistletoe, usually from the ash tree, is first infused intravenously daily over several days. This loads the body with high levels of lectins but the intravenous dosing does not yet activate the dendritic cells. Dendritic cells are special immune cells that can activate and direct the cancer killing T cells of the immune system. A very high dose below the skin (subcutaneously) is then administered. This is where the dendritic cells live and they are activated especially strongly1. A fever of over 102ºF is often noted. Like a healthy fever this process is self regulated by the body. Patients need to have some reserve of vitality and be able to tolerate several days of fever, often with chills, body aches and feelings of malaise- usually over 2 weeks. But these fevers often hold an emotionally transformative power. Many of my patients have described lucid dreams. One patient had always had sleep disturbed by anxiety but had a lucid and peaceful experience of frankly speaking to her breast cancer, telling it that it has served its purpose and it may go now. This was accompanied by a regression of the tumor.

This Heat Seeking Mistletoe therapy as well as high dose intravenous therapy have been the methods most often associated with spontaneous remissions. Dr Maurice Orange reports on using this method and noting complete remissions from several cancers2. This case series included in a dissertation on mistletoe includes patients who used only mistletoe as treatment for their cancers (excluding chemotherapy and often surgery)3.

The Heat Seeking Mistletoe protocol will commonly give symptoms of short term, local inflammation where tumor is located. Patients treated in the Martin Clinic Healing House have reported such symptoms during the induction phase. A patient with cancerous tumors in her lungs from stage 4 breast cancer reported a non productive cough. Chest xray was negative for pneumonia or other concerning process. Several weeks later a chest CT scan showed her tumors had shrunk to less than half the size. Another patient had metastasis from colon cancer in her spine and liver. She had an achy pain in her right abdomen where her liver was, as well as similar pain in her spine and in her lower abdomen where her primary tumor was located. This occurred the day after her first treatment and corresponded with a robust remission that baffled her conventionally trained oncologist. These body pains are typically temporary and they represent an immune reaction to the tumor. Immune identification results in a robust attack against the tumor and changes the extracellular matrix (the body’s terrain) to resist further growth or metastasis.

One picture of cancer therapy is the untying of a series of knots. Usually one needs to gently loosen from many angles these knots. Similarly with cancer we should work from many sides- working on not only the tumor, but diet, removing toxins from the environment, decreasing (long term) inflammation, emotional and spiritual, artistic, biographically and socially. The Heat Seeking Mistletoe protocol is a strong initial approach in this process usually reserved for turning the tide when strong measures are needed. Acute inflammation is used to resolve chronic inflammation in the same way that often a febrile state may resolve some chronic conditions.

High Dose Intravenous Mistletoe Therapy

The High Dose Mistletoe protocols are another strong way of working with cancer. High doses of mistletoe are infused intravenously. Two commonly used brands of mistletoe are Helixor and Abnoba. Fermented mistletoe preparations are generally always avoided in intravenous use due to the higher risk of allergic reaction, which is quite low with Helixor and Abnoba. Intravenous protocols with Helixor usually start with 50 to 100mg and will use either A,M, or P (Fir, Apple, or Pine). Daily or every other day injections are performed for 2 weeks- injections are held if there is fever. A similar regimen is used with Abnoba products but at doses of 20 to 60mg as abnoba has much more fever producing lectins than Helixor.  As the subcutaneous injections are not immediately performed and the dendritic cells are not stimulated, there typically are not high fevers or flu like symptoms though these occur occasionally. The infusion dose is doubled each infusion until 800mg Helixor dose is reached or until any of the fever effects are reached. After this induction infusions are continued regularly- from weekly to once a month. Other methods are to transition to a high dose subcutaneous administration…

Read the rest of this article at https://martin-clinic.com/?p=153

Conclusion

Mistletoe has a vast role in cancer. Whether it is used as an additional agent for reducing chemotherapy side effects, or as the cornerstone of a transformative cancer treatment when no other hope has been given, it stands as the safest, most evidence based natural treatment for cancer in existence. It is time for this popular European medicine to become adopted around the world.

1.
Saha C, Das M, Stephen-Victor E, Friboulet A, Bayry J, Kaveri S. Differential Effects of Viscum album Preparations on the Maturation and Activation of Human Dendritic Cells and CD4+ T Cell Responses. Molecules. 2016;21(7):912. doi: 10.3390/molecules21070912
2.
Orange M, Lace A, Fonseca MP, Von Laue BH, Geider S, Kienle GS. Durable Regression of Primary Cutaneous B-Cell Lymphoma following Fever-inducing Mistletoe Treatment: Two Case Reports. Global Advances in Health and Medicine. 2012;1(1):18-25. doi: 10.7453/gahmj.2012.1.1.006
3.
Orange M. School of Cancer Sciences, Birmingham UK. Mistletoe Therapy for Cancer Patients. http://www.anthromed.org/UploadedDocuments/0_Dissertation_compressed.pdf. Published August 2010.
4.
Kienle GS, Grugel R, Kiene H. Safety of higher dosages of Viscum album L. in animals and humans – systematic review of immune changes and safety parameters. BMC Complementary and Alternative Medicine. 2011;11(1). doi: 10.1186/1472-6882-11-72
5.
Hutt N, Kopferschmitt-Kubler M, Cabalion J, Purohit A, Alt M, Pauli G. Anaphylactic reactions after therapeutic injection of mistletoe (Viscum album L.). Allergol Immunopathol (Madr). 2001;29(5):201-203. [PubMed]
6.
Bock P, Hanisch J, Matthes H, Zänker K. Targeting Inflammation in Cancer-Related-Fatigue: A Rationale for Mistletoe Therapy as Supportive Care in Colorectal Cancer Patients. Inflamm Allergy Drug Targets. 2014;13(2):105-111. [PMC]
7.
Kim K, Yook J, Eisenbraun J, Kim B, Huber R. Quality of life, immunomodulation and safety of adjuvant mistletoe treatment in patients with gastric carcinoma – a randomized, controlled pilot study. BMC Complement Altern Med. 2012;12:172. [PubMed]
8.
Brandenberger M, Simões-Wüst A, Rostock M, Rist L, Saller R. An exploratory study on the quality of life and individual coping of cancer patients during mistletoe therapy. Integr Cancer Ther. 2012;11(2):90-100. [PubMed]
9.
Kienle G, Mussler M, Fuchs D, Kiene H. Intravenous Mistletoe Treatment in Integrative Cancer Care: A Qualitative Study Exploring the Procedures, Concepts, and Observations of Expert Doctors. Evid Based Complement Alternat Med. 2016;2016:4628287. [PubMed]
10.
Orange M, Reuter U, Hobohm U. Coley’s Lessons Remembered: Augmenting Mistletoe Therapy. Integr Cancer Ther. 2016;15(4):502-511. [PubMed]
11.
Kienle G, Kiene H. Complementary cancer therapy: a systematic review of prospective clinical trials on anthroposophic mistletoe extracts. Eur J Med Res. 2007;12(3):103-119. [PubMed]
12.
Winters N, Higgins Kelly J. The Metabolic Approach to Cancer: Integrating Deep Nutrition, the Ketogenic Diet, and Nontoxic Bio-Individualized Therapies. Chelsea Green Publishing ; 2017.
13.
Kirsch A. Successful treatment of metastatic malignant melanoma with Viscum album extract (Iscador M). J Altern Complement Med. 2007;13(4):443-445. [PubMed]
14.
von S-A, Goyert A, Vagedes J, Kiene H, Merckens H, Kienle G. Disappearance of an advanced adenomatous colon polyp after intratumoural injection with Viscum album (European mistletoe) extract: a case report. J Gastrointestin Liver Dis. 2014;23(4):449-452. [PubMed]
15.
Schad F, Atxner J, Buchwald D, et al. Intratumoral Mistletoe (Viscum album L) Therapy in Patients With Unresectable Pancreas Carcinoma: A Retrospective Analysis. Integr Cancer Ther. 2014;13(4):332-340. [PubMed]
16.
Orange M, Lace A, Fonseca M, von L, Geider S, Kienle G. Durable Regression of Primary Cutaneous B-Cell Lymphoma Following Fever-inducing Mistletoe Treatment: Two Case Reports. Glob Adv Health Med. 2012;1(1):18-25. [PubMed]
17.
Werthmann P, Sträter G, Friesland H, Kienle G. Durable response of cutaneous squamous cell carcinoma following high-dose peri-lesional injections of Viscum album extracts–a case report. Phytomedicine. 2013;20(3-4):324-327.[PubMed]
18.
Steele M, Axtner J, Happe A, Kröz M, Matthes H, Schad F. Use and safety of intratumoral application of European mistletoe (Viscum album L) preparations in Oncology. Integr Cancer Ther. 2015;14(2):140-148. [PubMed]
19.
Elsässer-Beile U, Leiber C, Wetterauer U, et al. Adjuvant intravesical treatment with a standardized mistletoe extract to prevent recurrence of superficial urinary bladder cancer. Anticancer Res. 2005;25(6C):4733-4736. [PubMed]
20.
Gaafar R, Abdel R, Aboulkasem F, El B. Mistletoe preparation (Viscum Fraxini-2) as palliative treatment for malignant pleural effusion: a feasibility study with comparison to bleomycin. Ecancermedicalscience. 2014;8:424. [PubMed]
21.
Stange R, Jänsch A, Schrag S, et al. [Favourable course of persisting malignant ascites]. Forsch Komplementmed. 2009;16(1):49-53. [PubMed]